Approval date

Mental health problems and poor sleep are associated with increased risk of heart disease. However, mental health and poor sleep often occur together. The objective of this study is to determine if poor sleep and poor mental health are independent risk factors for incident heart disease.

The incidence of heart diseases will compare six groups: a) no depression and normal sleep duration; b) no depression and short sleep duration; c) no depression and long sleep duration; d) depression and normal sleep duration; e) depression and short sleep duration; and f) depression and long sleep duration. The above analyses will be repeated with anxiety. CARTaGENE data are used because the large sample is expected to provide sufficient power for the mentioned analyses. Moreover, detailed assessments of risk variables were collected and this data can be linked to measures of any variable of interest in heart diseases.