{"id":1567,"date":"2026-07-27T14:37:39","date_gmt":"2026-07-27T18:37:39","guid":{"rendered":"https:\/\/cartagene.qc.ca\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/"},"modified":"2026-07-31T14:56:09","modified_gmt":"2026-07-31T18:56:09","slug":"genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene","status":"publish","type":"projet","link":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/","title":{"rendered":"Genetic analyses of proposed new ovarian cancer predisposing gene"},"content":{"rendered":"<div class=\"htb htb-hero-simple htb-hero-simple--js   default-margin-top  default-margin-bottom  bg-color color-none  htb-uid-1 \" >\n\t<div class=\"container-fluid\">\n\t\t<div class=\"row\">\n\t\t\t<div class=\"col-12 \">\n\t\t\t\t<div class=\"content-box \">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"henri-breadcrumb-box\">\n\t\t\t<nav aria-label=\"breadcrumb\">\n\t\t\t\t<ol class=\"breadcrumb\" itemscope itemtype=\"http:\/\/schema.org\/BreadcrumbList\">\n\t\t\t\t\t\t\t\t\t\t<li class=\"breadcrumb-item \" itemprop=\"itemListElement\" itemtype=\"http:\/\/schema.org\/ListItem\">\n\t\t\t\t\t\t<a href=\"https:\/\/cartagene.qc.ca\/en\/\">Home<\/a><\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"breadcrumb-item\" itemprop=\"itemListElement\" itemtype=\"http:\/\/schema.org\/ListItem\">\n\t\t\t\t\t\t\t\t<a href=\"\/en\/projects\">Projects<\/a><\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li class=\"breadcrumb-item active\" aria-current=\"page\" itemprop=\"itemListElement\" itemtype=\"http:\/\/schema.org\/ListItem\">Genetic analyses of proposed new ovarian cancer predisposing gene<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/ol>\n\t\t\t<\/nav>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h1 >Genetic analyses of proposed new ovarian cancer predisposing gene<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n\n<div class=\"htb htb-fiche_technique   default-margin-top  default-margin-bottom  bg-color color-none  htb-uid-2 \" >\n\n\t\n\t\t\t<div class=\"container-xxl\">\n\t\t\t<div class=\"row\">\n\t\t\t\t<div class=\"col-12\">\n\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-grille\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-grille__rangee\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-carte bg-color color-bleu-blanc\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__label\">Status<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__valeur\">Completed<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-carte bg-color color-bleu-blanc\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__label\">Start date<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__valeur\">2018<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-carte bg-color color-bleu-blanc\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__label\">Location<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__valeur\">Quebec<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-grille__rangee\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-carte bg-color color-bleu-blanc\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__label\">Researcher<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__valeur\">Tonin, Patricia<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-carte bg-color color-bleu-blanc\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__label\">Associated institution<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"ft-carte__valeur\">The Research Institute of the McGill University Health Centre and McGill University<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__row row\">\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__label-col col-12 col-lg-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"surtitre\">Summary<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__body-col col-12 col-lg-8\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__texte\"><p>A significant proportion of hereditary ovarian cancer cases cannot be explained by BRCA1 or BRCA2 mutations. This project aimed to identify new susceptibility genes by focusing on DNA repair pathways. Genetic analyses identified a rare variant in the FANCI gene, more frequent in the French-Canadian population and associated with impaired DNA repair. Frequency analyses using datasets including CARTaGENE suggest this variant may contribute to cancer risk. The findings highlight the role of multiple rare variants and improve understanding of the genetic basis of ovarian cancer.<\/p>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__row row\">\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__label-col col-12 col-lg-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"surtitre\">Themes<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__body-col col-12 col-lg-8\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__texte\"><ul>\n<li>Cancer<\/li>\n<li>Genetics and genomics<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__row row\">\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__label-col col-12 col-lg-4\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"surtitre\">Data types<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__body-col col-12 col-lg-8\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"ft-contenu__texte\"><ul>\n<li>Genetic data<\/li>\n<li>Questionnaire data<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\n<\/div>\n\n\n<div class=\"htb htb-liste-posts-simple   default-margin-top  default-margin-bottom  bg-color color-none  htb-uid-3 \" >\n\t<div class=\"container-xxl\">\n\t\t\t\t\t<div class=\"htb-liste-posts-simple-header\">\n\t\t\t\t\t\t\t\t\t<div class=\"header-intro\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\t\t\t\t<h2 >Related resources<\/h2>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\n\t\t\t\t\t<div class=\"row posts-container\">\n\t\t\t\t<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Publications<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2026\/01\/20\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1\/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41596682\" target=\"_blank\" rel=\"noopener\" aria-label=\"The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1\/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers\">The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1\/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Theses and dissertations<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2023\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>A molecular genetic investigation of FANCI as a new candidate ovarian cancer predisposing gene<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/escholarship.mcgill.ca\/concern\/theses\/w6634896h\" target=\"_blank\" rel=\"noopener\" aria-label=\"A molecular genetic investigation of FANCI as a new candidate ovarian cancer predisposing gene\">A molecular genetic investigation of FANCI as a new candidate ovarian cancer predisposing gene<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Theses and dissertations<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2023\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>The genetic analyses of DNA repair pathway genes in French Canadians of Quebec identified new candidate risk variants implicated in hereditary ovarian cancer<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/escholarship.mcgill.ca\/concern\/theses\/ws859m938\" target=\"_blank\" rel=\"noopener\" aria-label=\"The genetic analyses of DNA repair pathway genes in French Canadians of Quebec identified new candidate risk variants implicated in hereditary ovarian cancer\">The genetic analyses of DNA repair pathway genes in French Canadians of Quebec identified new candidate risk variants implicated in hereditary ovarian cancer<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Publications<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2023\/03\/08\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36969007\" target=\"_blank\" rel=\"noopener\" aria-label=\"Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases\">Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Publications<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2023\/01\/20\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36833203\" target=\"_blank\" rel=\"noopener\" aria-label=\"Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene\">Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Publications<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2022\/04\/30\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35565380\" target=\"_blank\" rel=\"noopener\" aria-label=\"The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population\">The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Theses and dissertations<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2021\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>Analyzing the genetic landscape of French-Canadian hereditary breast cancer women that carry pathogenic BRCA1 or BRCA2 variants<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/escholarship.mcgill.ca\/concern\/theses\/8p58pj78x?locale=en\" target=\"_blank\" rel=\"noopener\" aria-label=\"Analyzing the genetic landscape of French-Canadian hereditary breast cancer women that carry pathogenic BRCA1 or BRCA2 variants\">Analyzing the genetic landscape of French-Canadian hereditary breast cancer women that carry pathogenic BRCA1 or BRCA2 variants<\/a>\n\t<\/div>\n<\/article>\n<article class=\"htb-post-list-item post-type-post\">\n\t<div class=\"contenu-box\">\n\t\t\t\t\t\t\t<div class=\"post-top-box\">\n\t\t\t\t<div class=\"eyebrow-box\">\n\t\t\t\t\t<span class=\"surtitre\">Publications<\/span>\n\t\t\t\t\t<span class=\"year-txt\">\n\t\t\t\t\t\t2021\/12\/03\t\t\t\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"title-box\">\n\t\t\t\t\t<h3>A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"post-footer-box\">\n\t\t\t\t<span class=\"see-more-txt\">View publication<\/span>\n\t\t\t\t<span class=\"bt-arrow bt-arrow--externe\" aria-hidden=\"true\"><\/span>\n\t\t\t<\/div>\n\t\t\t\t<a class=\"stretched-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34861889\" target=\"_blank\" rel=\"noopener\" aria-label=\"A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene\">A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene<\/a>\n\t<\/div>\n<\/article>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","projet-categorie":[],"projet-status":[50],"projet-thematique":[54,51],"projet-type-donnees":[62,58],"projet-localisation":[64],"class_list":["post-1567","projet","type-projet","status-publish","hentry","projet-status-completed","projet-thematique-cancer","projet-thematique-genetics-and-genomics","projet-type-donnees-genetic-data","projet-type-donnees-questionnaire-data","projet-localisation-quebec-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/\" \/>\n<meta property=\"og:site_name\" content=\"CARTaGENE\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-31T18:56:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cartagene.qc.ca\/wp-content\/uploads\/2026\/06\/og-image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/projet\\\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\\\/\",\"url\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/projet\\\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\\\/\",\"name\":\"Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#website\"},\"datePublished\":\"2026-07-27T18:37:39+00:00\",\"dateModified\":\"2026-07-31T18:56:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/projet\\\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/projet\\\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/projet\\\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Genetic analyses of proposed new ovarian cancer predisposing gene\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/\",\"name\":\"CARTaGENE\",\"description\":\"Cohorte et biobanque Qu\u00e9bec\",\"publisher\":{\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#organization\",\"name\":\"CARTaGENE\",\"url\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/cartagene.qc.ca\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/CARTaGENE_Logos_RVB_Principal_Bicolore_Fonce.svg\",\"contentUrl\":\"https:\\\/\\\/cartagene.qc.ca\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/CARTaGENE_Logos_RVB_Principal_Bicolore_Fonce.svg\",\"width\":1,\"height\":1,\"caption\":\"CARTaGENE\"},\"image\":{\"@id\":\"https:\\\/\\\/cartagene.qc.ca\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/","og_locale":"en_US","og_type":"article","og_title":"Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE","og_url":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/","og_site_name":"CARTaGENE","article_modified_time":"2026-07-31T18:56:09+00:00","og_image":[{"width":1200,"height":630,"url":"https:\/\/cartagene.qc.ca\/wp-content\/uploads\/2026\/06\/og-image-1.png","type":"image\/png"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/","url":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/","name":"Genetic analyses of proposed new ovarian cancer predisposing gene | CARTaGENE","isPartOf":{"@id":"https:\/\/cartagene.qc.ca\/en\/#website"},"datePublished":"2026-07-27T18:37:39+00:00","dateModified":"2026-07-31T18:56:09+00:00","breadcrumb":{"@id":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cartagene.qc.ca\/en\/projet\/genetic-analyses-of-proposed-new-ovarian-cancer-predisposing-gene\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cartagene.qc.ca\/en\/"},{"@type":"ListItem","position":2,"name":"Genetic analyses of proposed new ovarian cancer predisposing gene"}]},{"@type":"WebSite","@id":"https:\/\/cartagene.qc.ca\/en\/#website","url":"https:\/\/cartagene.qc.ca\/en\/","name":"CARTaGENE","description":"Cohorte et biobanque Qu\u00e9bec","publisher":{"@id":"https:\/\/cartagene.qc.ca\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cartagene.qc.ca\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cartagene.qc.ca\/en\/#organization","name":"CARTaGENE","url":"https:\/\/cartagene.qc.ca\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cartagene.qc.ca\/en\/#\/schema\/logo\/image\/","url":"https:\/\/cartagene.qc.ca\/wp-content\/uploads\/2026\/06\/CARTaGENE_Logos_RVB_Principal_Bicolore_Fonce.svg","contentUrl":"https:\/\/cartagene.qc.ca\/wp-content\/uploads\/2026\/06\/CARTaGENE_Logos_RVB_Principal_Bicolore_Fonce.svg","width":1,"height":1,"caption":"CARTaGENE"},"image":{"@id":"https:\/\/cartagene.qc.ca\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet\/1567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet"}],"about":[{"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/types\/projet"}],"version-history":[{"count":3,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet\/1567\/revisions"}],"predecessor-version":[{"id":3224,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet\/1567\/revisions\/3224"}],"wp:attachment":[{"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/media?parent=1567"}],"wp:term":[{"taxonomy":"projet-categorie","embeddable":true,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet-categorie?post=1567"},{"taxonomy":"projet-status","embeddable":true,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet-status?post=1567"},{"taxonomy":"projet-thematique","embeddable":true,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet-thematique?post=1567"},{"taxonomy":"projet-type-donnees","embeddable":true,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet-type-donnees?post=1567"},{"taxonomy":"projet-localisation","embeddable":true,"href":"https:\/\/cartagene.qc.ca\/en\/wp-json\/wp\/v2\/projet-localisation?post=1567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}