Publications
2019
Z. Slim, C.S. Moura, S. Bernatsky, E. Rahme, Capture of Rheumatoid Arthritis Cases within Quebec Health Administrative Database, J Rheumatol.
Z. Slim, C.S. Moura, S. Bernatsky, E. Rahme, Care quality for rheumatoid arthritis patients in Quebec, Int J Rheum Dis
I. Fortier, N. Dragieva, M. Saliba, C. Craig, P.J. Robson; with the Canadian Partnership for Tomorrow Project’s scientific directors and the Harmonization Standing Committee, Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis, CMAJ Open 7(2):E272-E282
F. Wünnemann, K.S. Lo, A. Langford-Avelar, D. Busseuil, M.P. Dubé, J.C. Tardif, G. Lettre , Validation of Genome-wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians, Circ Genom Precis Med.
H.D. Hosgood III, M. Klugman, K. Matsuo, A.J. White, A. Sadakane, X.O. Shu, R. Lopez-Ridaura, A. Shin, I. Tsuji, R. Malekzadeh, Nolwenn Noisel et al., The Establishment of the Household Air Pollution Consortium (HAPCO), Atmosphere 10(7): 422
P. Hystad, Y. Payette, N. Noisel, C. Boileau, Green space associations with mental health and cognitive function, Environ Epidemiol 3(1):e040
A.T. Ali, L. Boehme, G. Carbajosa, V.C. Seitan, K.S. Small, A. Hodgkinson, Nuclear genetic regulation of the human mitochondrial transcriptome, eLife 8:e41927
L.-C. Desbiens, R. Goupil, A. Sidibé, F. Madore, F. Mac-Way, Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey, Osteoporos Int. 30(4):787-795
2018
M.J. Favé, F.C. Lamaze, D. Soave, A. Hodgkinson, H. Gauvin, V. Bruat, J.C. Grenier, E. Gbeha, K. Skead, A. Smargiassi, M. Johnson, Y. Idaghdour, P. Awadalla, Gene-by-environment interactions in urban populations modulate risk phenotypes, Nat Commun. 9(1):827
D. Nada, C. Julien, M.E. Samuels, A. Moreau, A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population, Spine (Phila Pa 1976) 43(3):172-178
R. Goupil, M. Lamarre-Cliche, M. Vallée, The 2017 American College of Cardiology/American Heart Association vs Hypertension Canada High Blood Pressure Guidelines and Potential Implications, The Canadian Journal of Cardiology 34(5):665-669
T.J.B. Dummer, P. Awadalla, C. Boileau, C. Craig, I. Fortier, V. Goel, J.M.T. Hicks, S. Jacquemont, B.M. Knoppers, N. Le, T. McDonald, J. McLaughlin, A.M. Mes-Masson, A.M. Nuyt, L.J. Palmer, L. Parker, M. Purdue, et al., The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention, CMAJ 190(23):E710-E717
R.J. Burns, S.S. Deschênes, N. Schmitz, Associations between Depressive Symptoms and Indices of Obesity in Adults with Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study, Canadian Journal of Diabetes S1499-2671(18)30030-3
S. Peischl, I. Dupanloup, A. Foucal, M. Jomphe, V. Bruat, J.C. Grenier, A. Gouy, K.J. Gilbert, E. Gbeha, L. Bosshard, E. Hip-Ki, M. Agbessi, A. Hodgkinson, H. Vézina, P. Awadalla, L. Excoffier, Relaxed Selection During a Recent Human Expansion, Genetics 208(2):763-777
A. Krajcoviechova, F.C. Marois-Blanchet, S. Troyanov, F. Harvey, P. Dumas, J. Tremblay, R. Cifkova, P. Awadalla, F. Madore, P. Hamet, Uromodulin in a pathway between decreased renal urate excretion and albuminuria, Am J Hypertens 32(4):384-392
F. Lamarche, M. Agharazii, A.C. Nadeau-Fredette, F. Madore, R. Goupil, Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis, Hypertension 71(3):415-421
F. Lepeytre, P. L. Lavoie, S. Troyanov, F. Madore, M. Agharazii, R. Goupil, Uric acid association with pulsatile and steady components of central and peripheral blood pressures, Journal of Hypertension 0263-6352
2017
A.M. Drucker, A.A. Qureshi, T.J.B. Dummer, L. Parker, W.Q. Li, Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project, Br J Dermatol. 177(4):1043-1051
A. Gravel, I. Dubuc, A. Brooks-Wilson, K.J. Aronson, J. Simard, H.A. Velásquez-García, J.J. Spinelli, L. Flamand, Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Cancer Epidemiol Biomarkers Prev 26(3):425-427
M. Tremblay, G. Rouleau, Deep genealogical analysis of a large cohort of participants in the CARTaGENE project (Quebec, Canada), Annals of Human Biology 44(4):357-365
C. Dias, M. Giordano, R. Frechette, S. Bellone, C. Polychronakos, L. Legault, C.L. Deal, C.G. Goodyer, Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature, J Cell Mol Med 21(11):2985-2999
S. Bernatsky, A. Smargiassi, L. Joseph, P. Awadalla, I. Colmegna, M. Hudson, M.J. Fritzler, Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies, Environ Res 157:60-63
S. Boies, C. Mérette, T. Paccalet, M. Maziade, A. Bureau, Polygenic risk scores distinguish patients from non-affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi-affected kindreds, Am J Med Genet B Neuropsychiatr Genet.
D.A. Knowles, J.R. Davis, H. Edgington, A. Raj, M.J. Favé, X. Zhu, J.B. Potash, M.M. Weissman, J. Shi, D. Levinson, P. Awadalla, S. Mostafavi, S.B. Montgomery, A. Battle, Allele-specific expression reveals interactions between genetic variation and environment, Nature Methods 14(7):699-702
2016
K.R. Kukurba, P. Parsana, B. Balliu, K.S. Smith, Z. Zappala, D.A. Knowles, M.J. Favé, J.R. Davis, X. Li, X. Zhu, J.B. Potash, M.M. Weissman, J. Shi, A. Kundaje, D.F. Levinson, P. Awadalla, S. Mostafavi, A. Battle, S.B. Montgomery, Impact of the X Chromosome and sex on regulatory variation, Genome Res. 26(6):768-77
S. Troyanov, C. Delmas-Frenette, G. Bollée, S. Youhanna, V. Bruat, P. Awadalla, O. Devuyst, F. Madore, Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion, Clin J Am Soc Nephrol 11(1): 62-69
A. Hodgkinson, J.C. Grenier, E. Gbeha, P. Awadalla, Haplotype-based normalization technique for the analysis and detection of allele specific expression, BMC Bioinformatics 17(1): 364
N.D. Merner, A. Mercado, A.R. Khanna, A. Hodgkinson, V. Bruat, P. Awadalla, G. Gamba, G.A. Rouleau, K.T. Kahle, Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia, J Psychiatr Res 77: 22-26
R. Goupil, D. Dupuis, S. Troyanov, F. Madore, M. Agharazii, Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis, J Hypertens 34(8): 1535-1543
S.S. Deschênes, R.J. Burns, E. Graham, N. Schmitz, Prediabetes, depressive and anxiety symptoms, and risk of type 2 diabetes: A community-based cohort study, J Psychosom Res. 89:85-90
R. Goupil, D. Dupuis, M. Agharazii, P. Hamet, S. Troyanov, F. Madore, Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE, Nephrol Dial Transplant 32(6):976-983
N. Schmitz, S.S. Deschênes, R.J. Burns, K.J. Smith, A. Lesage, I. Strychar, R. Rabasa-Lhoret, C. Freitas, E. Graham, P. Awadalla, J.L. Wang, Depression and risk of type 2 diabetes: the potential role of metabolic factors, Mol Psychiatry 21(12):1726-1732
S.S. Anand, J.V. Tu, P. Awadalla, S. Black, C. Boileau, D. Busseuil, D. Desai, J.P. Despres, R.J. de Souza, T.J.B. Dummer, S. Jacquemont, B.M. Knoppers, E. Larose, S.A. Lear, F. Marcotte, A.R. Moody, L. Parker, P. Poirier, et al., Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) - a Pan Canadian cohort study, BMC Public Health 32(6):976-983
2015
A. Gravel, I. Dubuc, G. Morissette, R.H. Sedlak, K. R. Jerome, L. Flamand, Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris, Proc Natl Acad Sci U S A 112(26):8058-63
C.S. Moura, S.S. Daskalopoulou, L.E. Levesque, S. Bernatsky, M. Abrahamowicz, M.A. Tsadok, S. Rajabi, L. Pilote, Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients, J Clin Hypertens (Greenwich) 17(11): 848-854
J.G. Hussin, A. Hodgkinson, Y. Idaghdour, J.C. Grenier, J.P. Goulet, E. Gbeha, E. Hip-Ki, P. Awadalla, Recombination affects accumulation of damaging and disease-associated mutations in human populations, Nat Genet 47(4): 400-404
R. El-Bikai, M.R. Tahir, J. Tremblay, M. Joffres, O. Seda, L. Sedova, P. Awadalla, C. Laberge, B.M. Knoppers, P. Dumas, D. Gaudet, L.G. Ste-Marie, P. Hamet, Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals, J Hypertens 33(4): 727-735
2014
A. Hodgkinson, Y. Idaghdour, E. Gbeha, J.C. Grenier, E. Hip-Ki, V. Bruat, J.P. Goulet, T. de Malliard, P. Awadalla, High-resolution genomic analysis of human mitochondrial RNA sequence variation, Science 344(6182): 413-415
K.T. Kahle, N. D. Merner, P. Friedel, L. Silayeva, B. Liang, A. Khanna, Y. Shang, P. Lachance-Touchette, C. Bourassa, A. Levert, P.A. Dion, B. Walcott, D. Spiegelman, A. Dionne-Laporte, A. Hodgkinson, P. Awadalla, H. Nikbakht, J. Majewski, P. Cossette, Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy, EMBO Rep 15(7): 766-774
J.C. Verhave, S. Troyanov, F. Mongeau, L. Fradette, J. Bouchard, P. Awadalla, F. Madore, Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care, Clin J Am Soc Nephrol 9(4): 713-719
2013
D. Doiron, P. Raina and I. Fortier, Linking Canadian population health data: maximizing the potential of cohort and administrative data, Canadian Journal of Public Health 104(3): e258–e261
P. Awadalla, C. Boileau, Y. Payette, Y. Idaghdour, J. P. Goulet, B.M. Knoppers, P. Hamet, C. Laberge, Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics, Int J Epidemiol 42(5): 1285-1299
2011
S. Fortin, S. Pathmasiri, R. Grintuch, M. Deschênes, Access arrangements' for biobanks: a fine line between facilitating and hindering collaboration, Public Health Genomics 14(2): 104-114
2007
B. Godard, J. Marshall, C. Laberge, Community engagement in genetic research: results of the first public consultation for the Quebec CARTaGENE project, Community Genet 10(3): 147-158
2006
Y. Joly, B.M. Knoppers, Pharmacogenomic data sample collection and storage: ethical issues and policy approaches, Pharmacogenomics 7(2): 219-226
2004
B. Godard, J. Marshall, C. Laberge, B.M. Knoppers, Strategies for consulting with the community: the cases of four large-scale genetic databases, Sci Eng Ethics 10(3): 457-477
Projets
2019
Aging-induced dysregulation of gene expression networks Chercheur principal: Alan Cohen
Affiliation: Université de Sherbrooke
Nutritional, behavioral and lifestyle mediators of genetic susceptibility to obesity Chercheur principal: Louis Pérusse
Affiliation: Université Laval
Lifestyle and Cancer: Identifying new risk factors for the most common cancers in Canada Chercheur principal: Rachel Murphy
Affiliation: The Université of British Columbia
Longitudinal Genome and Phenome Analyses of Human Populations Chercheur principal: Philip Awadalla
Affiliation: Ontario Institute for Cancer Research
Évaluation de l’exposition des travailleurs à la chaleur à l’aide des données de la cohorte québécoise CARTaGENE Chercheur principal: Nolwenn Noisel
Affiliation: CARTaGENE - CHU Sainte-Justine / École de santé publique
Phénotype de polymorphismes du récepteur NTS1 de la neurotensine Chercheur principal: Philippe Sarret
Affiliation: Université de Sherbrooke
Lifestyle and environmental factors, DNA methylation and lung cancer risk Chercheur principal: Vikki Ho
Affiliation: CRCHUM
Genetic Variants Associated with Pain Reduction in Patients with Low Back Pain or Neuropathic Pain Chercheur principal: Luda Diatchenko
Affiliation: McGill University
Évaluation des biomarqueurs de sénescence cellulaire chez les participants de la cohorte CARTaGENE Chercheur principal: Francis Rodier
Affiliation: CRCHUM
2018
Prévalence de variantes dans les gènes NPC1 et NPC2 dans la population québécoise Chercheur principal: Martine Tétreault
Affiliation: Centre hospitalier de l’Université de Montréal - CHUM
Role of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis Chercheur principal: Alain Moreau
Affiliation: Centre Hospitalier Universitaire Sainte-Justine
Étude de prévalence de l'antigène de groupe sanguin D faible type 42 Chercheur principal: Josée Laganière
Affiliation: Héma-Québec
Exposure to ultraviolet radiation and the risk of hematologic malignancy and other site-specific cancer development Chercheur principal: Will King
Affiliation: Queens University
Occupational exposure to endocrine disrupting chemicals and colorectal cancer risk Chercheur principal: Vikki Ho
Affiliation: CRCHUM
Genetic analyses of proposed new ovarian cancer predisposing gene Chercheur principal: Patricia Tonin
Affiliation: McGill University Health Centre
An investigation of gene-environment interaction on eating behaviour and adiposity in a cohort of Quebec adults Chercheur principal: Daiva Nielsen
Affiliation: McGill University
Population genetics of pharmacogenes Chercheur principal: Julie Hussin
Affiliation: Institut de Cardiologie de Montréal Centre de Recherche - Université de Montréal
Phenome-wide AssociatioN studies of cardiometabolic Drug tArgets (PANDA) Chercheur principal: Benoit Arsenault
Affiliation: Institut universitaire de cardiologie et de pneumologie de Québec –Université Laval
2017
Comparative Genomewide Association of Aortic Stenosis With and Without Coronary Artery Disease Chercheur principal: George Thanassoulis
Affiliation: McGill University Health Centre
Occupational Physical Activity and Lung Cancer Chercheur principal: Vikki Ho
Affiliation: CRCHUM
Genetic analyses of cardiometabolic diseases and traits in CARTaGENE Chercheur principal: Guillaume Lettre
Affiliation: Institut de Cardiologie de Montréal Centre de Recherche
The impact of structural genomic variants on cognition in the general population Chercheur principal: Sébastien Jacquemont
Affiliation: CHU Sainte-Justine
Systemic inflammation and the risk of depression in people with type 2 diabetes: a prospective community study Chercheur principal: Norbert Schmitz
Affiliation: Douglas Mental Health University Institute
Pharmacogenetic study exploring the impact of a genetic variant in the CYP2R1 gene on the response to vitamin D replacement therapy Chercheur principal: Brent Richards
Affiliation: Lady Davis Institute - Jewish General Hospital
Evaluation of genetic variants identified through hereditary cancer gene discovery projects in a French Canadian control cohort Chercheur principal: William Foulkes
Affiliation: McGill University Health Centre
Genetic basis and modifiers of sleep disorders Chercheur principal: Simon Warby
Affiliation: Hôpital Sacré-Coeur de Montréal
Estimation de la prévalence de certaines mutations associées à un risque accru de cancer du sein, ainsi que du risque qui leur sont associées Chercheur principal: Jacques Simard
Affiliation: CHU de Québec
SNP discovery in myalgic encephalomyelitis (ME) Chercheur principal: Alain Moreau
Affiliation: CHU Ste-Justine
Genetics of REM sleep behavior disorder and conversion to Parkinson's disease Chercheur principal: Ziv Gan Or
Affiliation: McGill University
Marqueurs Ostéocytaires, Fractures et Évènements Cardiovasculaires en Insuffisance Rénale Chronique (MOFECIRC) Chercheur principal: Fabrice Mac-Way
Affiliation: Université Laval
2016
Genomic Analysis of the Mitochondrial Transcriptome Chercheur principal: Alan Hogkinson
Affiliation: King's College London
L'étude du rôle prédicteur de la pression aortique centrale dans la survenue d'événements cardiovasculaires Chercheur principal: Rémi Goupil
Affiliation: Hôpital Sacré-Coeur de Montréal
Deciphering the Genetic background of Restless Legs Syndrome Chercheur principal: Guy Rouleau
Affiliation: Institut neurologique de Montréal, Université McGill
Genomic follow-up of the susceptibility loci for schizophrenia and bipolar disorder in multi-affected families of Eastern Quebec Chercheur principal: Michel Maziade
Affiliation: Université Laval
Poor sleep and mental health: independent or overlapping risk factors for heart diseases? Chercheur principal: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
2015
Vegetarian diet, the metabolic syndrome, obesity and inflammatory status Chercheur principal: Isabel Fortier
Affiliation: Maelstrom, Université McGill
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Identification of genes involved in adolescent idiopathic Scoliosis Chercheur principal: Alain Moreau
Affiliation: CHU Sainte-Justine
Evaluation of coronary vascular disease among high cardiovascular risk patients in CARTaGENE Chercheur principal: Thao Huynh
Affiliation: Sanofi
Canadian Alliance for Healthy Hearts and Minds – Development of community health and health services profiles Chercheur principal: Jack Tu
Affiliation: Sunnybrook Health Sciences Centre
Simultaneous systematic monitoring of hormonal pathways in bipolar disorder using LC-based targeted and untargeted metabolomics Chercheur principal: Dajana Vuckovic
Affiliation: Université Concordia
Clinical implementation and Outcomes Evaluation of Blood-Based biomarkers for COPD management Chercheur principal: Elizabeth MacNamara
Affiliation: Hôpital général juif
2014
Human Growth Hormone Receptor: regulation of expression during development Chercheur principal: Cynthia Goodyer
Affiliation: Université McGill
Génétique de la Rhinosinusite chronique avec polypose nasale Chercheur principal: Martin Desrosiers
Affiliation: CHUM
The association between type II diabetes and physical activity in the Canadian Partnership for Tomorrow Project Chercheur principal: Zhijie (Michael) Yu
Affiliation: Dalhousie University
Étude bien-être émotionnel, facteurs métaboliques et l’état de santé Chercheur principal: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
The genome-wide association study of the principal components of the metabolic syndrome enriched with albumin/creatinine ratio regarding the OPTI-THERA research project Chercheur principal: Pavel Hamet
Affiliation: CHUM
Exploring the Potential of CARTaGENE for GIS-Based Epidemiology: A Pilot Study of Green Space and Mental Health Chercheur principal: Nolwenn Noisel
Affiliation: CHU Sainte-Justine, Université de Montréal
2013
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (2) Chercheur principal: François Madore
Affiliation: Hôpital Sacré-Coeur
Caractérisation des contributions génomiques et environnementales à la variation des phénotypes cardiovasculaires et métaboliques dans la population du Québec Chercheur principal: Philip Awadalla
Affiliation: CHU Sainte-Justine, Université de Montréal
Plateforme d’Innovation en Génomique des Scolioses Pédiatriques (GSP) : Des Gènes aux Tests - Diagnostiques Complets Chercheur principal: Alain Moreau
Affiliation: CHU Ste-Justine
Molecular dissection of congenital heart disease in the French Canadian population Chercheur principal: Gregor Andelfinger
Affiliation: CHU Ste-Justine
2012
Conséquences médicales de l’intégration chromosomique de l’herpès virus humain 6 Chercheur principal: Louis Flamand
Affiliation: Université Laval
Test de l’accumulation de mutations délétères lors d’expansions spatiales par séquençage d’exomes Chercheur principal: Laurent Excoffier
Affiliation: Université de Berne, Suisse
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Développement d’une plateforme pour le diagnostic moléculaire du syndrome de Zellweger au Québec Chercheur principal: Luigi Bouchard
Affiliation: Université de Sherbrooke
Analyse des caractéristiques généalogiques des participants au projet CARTaGENE Chercheur principal: Marc Tremblay
Affiliation: Université du Québec à Chicoutimi
Environment, Epigenetics, and Rheumatic Disease Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
2010
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (1) Chercheur principal: François Madore
Affiliation: Hôpital Sacré-Coeur
2009
Methylmercury exposure and urinary metabolic profile in Cree people from Northern Quebec Chercheur principal: Pierre Ayotte
Affiliation: Centre de recherche du CHUQ, Université Laval