Publications
2018
S. Peischl, I. Dupanloup, A. Foucal, M. Jomphe, V. Bruat, J.-C. Grenier, A. Gouy, K. J. Gilbert, E. Gbeha, L. Bosshard, E. Hip-Ki, M. Agbessi, A. Hodgkinson, H. Vézina, P. Awadalla, L. Excoffier, Relaxed Selection During a Recent Human Expansion, Genetics 208(2):763-777
F. Lamarche, M. Agharazii, A. C. Nadeau-Fredette, F. Madore, R. Goupil, Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis, Hypertension 71(3):415-421
M. J. Favé, F. C. Lamaze, D. Soave, A. Hodgkinson, H. Gauvin, V. Bruat, J.C. Grenier, E. Gbeha, K. Skead, A. Smargiassi, M. Johnson, Y. Idaghdour, P. Awadalla, Gene-by-environment interactions in urban populations modulate risk phenotypes, Nat Commun. 9(1):827
D. Nada, C. Julien, M. E. Samuels, A. Moreau, A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population, Spine (Phila Pa 1976) 43(3):172-178
2017
C. Dias, M. Giordano, R. Frechette, S. Bellone, C. Polychronakos, L. Legault, C. L. Deal, C. G. Goodyer, Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature, J Cell Mol Med 21(11):2985-2999
S. Bernatsky, A. Smargiassi, L. Joseph, P. Awadalla, I. Colmegna, M. Hudson, M.J. Fritzler, Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies, Environ Res 157:60-63
S. Boies, C. Mérette, T. Paccalet, M. Maziade, A. Bureau, Polygenic risk scores distinguish patients from non-affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi-affected kindreds, Am J Med Genet B Neuropsychiatr Genet.
F. Lepeytre, P. L. Lavoie, S. Troyanov, F. Madore, M. Agharazii, R. Goupil, Uric acid association with pulsatile and steady components of central and peripheral blood pressures, Journal of Hypertension 0263-6352
D. A. Knowles, J. R. Davis, H. Edgington, A. Raj, M. J. Favé, X. Zhu, J. B. Potash, M. M. Weissman, J. Shi, D. Levinson, P. Awadalla, S. Mostafavi, S. B. Montgomery, A. Battle, Allele-specific expression reveals interactions between genetic variation and environment, Nature Methods 14(7):699-702
A. M. Drucker, A. A. Qureshi, T. J. B. Dummer, L. Parker, W. Q. Li, Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project, Br J Dermatol. 177(4):1043-1051
A. Gravel, I. Dubuc, A. Brooks-Wilson, K. J. Aronson, J. Simard, H. A. Velásquez-García, J. J. Spinelli, L. Flamand, Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Cancer Epidemiol Biomarkers Prev 26(3):425-427
M. Tremblay, G. Rouleau, Deep genealogical analysis of a large cohort of participants in the CARTaGENE project (Quebec, Canada), Annals of Human Biology 44(4):357-365
2016
N. D. Merner, A. Mercado, A. R. Khanna, A. Hodgkinson, V. Bruat, P. Awadalla, G. Gamba, G. A. Rouleau and K. T. Kahle, Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia, J Psychiatr Res 77: 22-26
R. Goupil, D. Dupuis, S. Troyanov, F. Madore and M. Agharazii, Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis, J Hypertens 34(8): 1535-1543
R. Goupil, D. Dupuis, M. Agharazii, P. Hamet, S. Troyanov and F. Madore, Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE, Nephrol Dial Transplant 32(6):976-983
S. S. Anand, J. V. Tu, P. Awadalla, S. Black, C. Boileau, D. Busseuil, D. Desai, J. P. Despres, R. J. de Souza, T. Dummer, S. Jacquemont, B. Knoppers, E. Larose, S. A. Lear, F. Marcotte, A. R. Moody, L. Parker, P. Poirier, et al., Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) - a Pan Canadian cohort study, BMC Public Health 32(6):976-983
K. R. Kukurba, P. Parsana, B. Balliu, K. S. Smith, Z. Zappala, D. A. Knowles, M. J. Favé, J. R. Davis, X. Li, X. Zhu, J. B. Potash, M. M. Weissman, J. Shi, A. Kundaje, D. F. Levinson, P. Awadalla, S. Mostafavi, A. Battle, S. B. Montgomery, Impact of the X Chromosome and sex on regulatory variation, Genome Res. 26(6):768-77
S. Troyanov, C. Delmas-Frenette, G. Bollee, S. Youhanna, V. Bruat, P. Awadalla, O. Devuyst and F. Madore, Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion, Clin J Am Soc Nephrol 11(1): 62-69
A. Hodgkinson, J.-C. Grenier, E. Gbeha, P. Awadalla, Haplotype-based normalization technique for the analysis and detection of allele specific expression, BMC Bioinformatics 17(1): 364
2015
J. G. Hussin, A. Hodgkinson, Y. Idaghdour, J. C. Grenier, J. P. Goulet, E. Gbeha, E. Hip-Ki and P. Awadalla, Recombination affects accumulation of damaging and disease-associated mutations in human populations, Nat Genet 47(4): 400-404
R. El-Bikai, M. R. Tahir, J. Tremblay, M. Joffres, O. Seda, L. Sedova, P. Awadalla, C. Laberge, B. M. Knoppers, P. Dumas, D. Gaudet, L. G. Ste-Marie and P. Hamet, Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals, J Hypertens 33(4): 727-735
A. Gravel, I. Dubuc, G. Morissette, R.H. Sedlak, K. R. Jerome, L. Flamand, Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris, Proc Natl Acad Sci U S A 112(26):8058-63
C. S. Moura, S. S. Daskalopoulou, L. E. Levesque, S. Bernatsky, M. Abrahamowicz, M. A. Tsadok, S. Rajabi and L. Pilote, Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients, J Clin Hypertens (Greenwich) 17(11): 848-854
2014
J. C. Verhave, S. Troyanov, F. Mongeau, L. Fradette, J. Bouchard, P. Awadalla and F. Madore, Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care, Clin J Am Soc Nephrol 9(4): 713-719
A. Hodgkinson, Y. Idaghdour, E. Gbeha, J. C. Grenier, E. Hip-Ki, V. Bruat, J. P. Goulet, T. de Malliard and P. Awadalla, High-resolution genomic analysis of human mitochondrial RNA sequence variation, Science 344(6182): 413-415
K. T. Kahle, N. D. Merner, P. Friedel, L. Silayeva, B. Liang, A. Khanna, Y. Shang, P. Lachance-Touchette, C. Bourassa, A. Levert, P. A. Dion, B. Walcott, D. Spiegelman, A. Dionne-Laporte, A. Hodgkinson, P. Awadalla, H. Nikbakht, J. Majewski, P. Cossette, Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy, EMBO Rep 15(7): 766-774
2013
D. Doiron, P. Raina, I. Fortier; Linkage Between Cohorts and Health Care Utilization Data: Meeting of Canadian Stakeholders workshop participants, Linking Canadian population health data: maximizing the potential of cohort and administrative data, Canadian Journal of Public Health 104(3): e258–e261
P. Awadalla, C. Boileau, Y. Payette, Y. Idaghdour, J. P. Goulet, B. Knoppers, P. Hamet, C. Laberge and C. A. Project, Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics, Int J Epidemiol 42(5): 1285-1299
2011
S. Fortin, S. Pathmasiri, R. Grintuch and M. Deschenes, Access arrangements' for biobanks: a fine line between facilitating and hindering collaboration, Public Health Genomics 14(2): 104-114
2007
B. Godard, J. Marshall and C. Laberge, Community engagement in genetic research: results of the first public consultation for the Quebec CARTaGENE project, Community Genet 10(3): 147-158
2006
Y. Joly and B. M. Knoppers, Pharmacogenomic data sample collection and storage: ethical issues and policy approaches, Pharmacogenomics 7(2): 219-226
2004
B. Godard, J. Marshall, C. Laberge and B. M. Knoppers, Strategies for consulting with the community: the cases of four large-scale genetic databases, Sci Eng Ethics 10(3): 457-477
Projets
2018
Role of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis Chercheur principal: Alain Moreau
Affiliation: Centre Hospitalier Universitaire Sainte-Justine
2017
Estimation de la prévalence de certaines mutations associées à un risque accru de cancer du sein, ainsi que du risque qui leur sont associées Chercheur principal: Jacques Simard
Affiliation: CHU de Québec
SNP discovery in myalgic encephalomyelitis (ME) Chercheur principal: Alain Moreau
Affiliation: CHU Ste-Justine
Genetics of REM sleep behavior disorder and conversion to Parkinson's disease Chercheur principal: Ziv Gan Or
Affiliation: McGill University
Marqueurs Ostéocytaires, Fractures et Évènements Cardiovasculaires en Insuffisance Rénale Chronique (MOFECIRC) Chercheur principal: Fabrice Mac-Way
Affiliation: Université Laval
Comparative Genomewide Association of Aortic Stenosis With and Without Coronary Artery Disease Chercheur principal: George Thanassoulis
Affiliation: McGill University Health Centre
Occupational Physical Activity and Lung Cancer Chercheur principal: Vikki Ho
Affiliation: CRCHUM
Genetic analyses of cardiometabolic diseases and traits in CARTaGENE Chercheur principal: Guillaume Lettre
Affiliation: Institut de Cardiologie de Montréal Centre de Recherche
The impact of structural genomic variants on cognition in the general population Chercheur principal: Sébastien Jacquemont
Affiliation: CHU Sainte-Justine
Systemic inflammation and the risk of depression in people with type 2 diabetes: a prospective community study Chercheur principal: Norbert Schmitz
Affiliation: Douglas Mental Health University Institute
Pharmacogenetic study exploring the impact of a genetic variant in the CYP2R1 gene on the response to vitamin D replacement therapy Chercheur principal: Brent Richards
Affiliation: Lady Davis Institute - Jewish General Hospital
Evaluation of genetic variants identified through hereditary cancer gene discovery projects in a French Canadian control cohort Chercheur principal: William Foulkes
Affiliation: McGill University Health Centre
Genetic basis and modifiers of sleep disorders Chercheur principal: Simon Warby
Affiliation: Hôpital Sacré-Coeur de Montréal
2016
Deciphering the Genetic background of Restless Legs Syndrome Chercheur principal: Guy Rouleau
Affiliation: Institut neurologique de Montréal, Université McGill
Genomic follow-up of the susceptibility loci for schizophrenia and bipolar disorder in multi-affected families of Eastern Quebec Chercheur principal: Michel Maziade
Affiliation: Université Laval
Poor sleep and mental health: independent or overlapping risk factors for heart diseases? Chercheur principal: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
Genomic Analysis of the Mitochondrial Transcriptome Chercheur principal: Alan Hogkinson
Affiliation: King's College London
L'étude du rôle prédicteur de la pression aortique centrale dans la survenue d'événements cardiovasculaires Chercheur principal: Rémi Goupil
Affiliation: Hôpital Sacré-Coeur de Montréal
2015
Clinical implementation and Outcomes Evaluation of Blood-Based biomarkers for COPD management Chercheur principal: Elizabeth MacNamara
Affiliation: Hôpital général juif
Vegetarian diet, the metabolic syndrome, obesity and inflammatory status Chercheur principal: Isabel Fortier
Affiliation: Maelstrom, Université McGill
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Identification of genes involved in adolescent idiopathic Scoliosis Chercheur principal: Alain Moreau
Affiliation: CHU Sainte-Justine
Evaluation of coronary vascular disease among high cardiovascular risk patients in CARTaGENE Chercheur principal: Thao Huynh
Affiliation: Sanofi
Canadian Alliance for Healthy Hearts and Minds – Development of community health and health services profiles Chercheur principal: Jack Tu
Affiliation: Sunnybrook Health Sciences Centre
Simultaneous systematic monitoring of hormonal pathways in bipolar disorder using LC-based targeted and untargeted metabolomics Chercheur principal: Dajana Vuckovic
Affiliation: Université Concordia
2014
Human Growth Hormone Receptor: regulation of expression during development Chercheur principal: Cynthia Goodyer
Affiliation: Université McGill
Génétique de la Rhinosinusite chronique avec polypose nasale Chercheur principal: Martin Desrosiers
Affiliation: CHUM
The association between type II diabetes and physical activity in the Canadian Partnership for Tomorrow Project Chercheur principal: Zhijie (Michael) Yu
Affiliation: Dalhousie University
Étude bien-être émotionnel, facteurs métaboliques et l’état de santé Chercheur principal: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
The genome-wide association study of the principal components of the metabolic syndrome enriched with albumin/creatinine ratio regarding the OPTI-THERA research project Chercheur principal: Pavel Hamet
Affiliation: CHUM
Exploring the Potential of CARTaGENE for GIS-Based Epidemiology: A Pilot Study of Green Space and Mental Health Chercheur principal: Nolwenn Noisel
Affiliation: CHU Sainte-Justine, Université de Montréal
2013
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (2) Chercheur principal: François Madore
Affiliation: Hôpital Sacré-Coeur
Caractérisation des contributions génomiques et environnementales à la variation des phénotypes cardiovasculaires et métaboliques dans la population du Québec Chercheur principal: Philip Awadalla
Affiliation: CHU Sainte-Justine, Université de Montréal
Plateforme d’Innovation en Génomique des Scolioses Pédiatriques (GSP) : Des Gènes aux Tests - Diagnostiques Complets Chercheur principal: Alain Moreau
Affiliation: CHU Ste-Justine
Molecular dissection of congenital heart disease in the French Canadian population Chercheur principal: Gregor Andelfinger
Affiliation: CHU Ste-Justine
2012
Développement d’une plateforme pour le diagnostic moléculaire du syndrome de Zellweger au Québec Chercheur principal: Luigi Bouchard
Affiliation: Université de Sherbrooke
Analyse des caractéristiques généalogiques des participants au projet CARTaGENE Chercheur principal: Marc Tremblay
Affiliation: Université du Québec à Chicoutimi
Environment, Epigenetics, and Rheumatic Disease Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Conséquences médicales de l’intégration chromosomique de l’herpès virus humain 6 Chercheur principal: Louis Flamand
Affiliation: Université Laval
Test de l’accumulation de mutations délétères lors d’expansions spatiales par séquençage d’exomes Chercheur principal: Laurent Excoffier
Affiliation: Université de Berne, Suisse
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Chercheur principal: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
2010
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (1) Chercheur principal: François Madore
Affiliation: Hôpital Sacré-Coeur
2009
Methylmercury exposure and urinary metabolic profile in Cree people from Northern Quebec Chercheur principal: Pierre Ayotte
Affiliation: Centre de recherche du CHUQ, Université Laval