Deciphering the Genetic background of Restless Legs Syndrome

Restless legs syndrome is a common neurological disorder characterized by an irresistible urge to move the legs, particularly during periods of rest or before falling asleep. The condition can disrupt sleep and significantly affect quality of life. Although its causes are not fully understood, research has shown that genetics plays an important role in determining who develops the disorder. Using CARTaGENE data and biological samples, this project contributed to a large international study aimed at identifying genetic variants associated with restless legs syndrome. The findings helped confirm the role of several previously identified genomic regions and contributed to the discovery of additional genetic factors involved in the condition. This research has improved our understanding of the biological mechanisms underlying restless legs syndrome and may support the development of improved diagnostic tools and future treatments.

• Chronic diseases
• Genetics and genomics

• Biological samples
• Questionnaire data