Genetic analyses of cardiometabolic diseases and traits in CARTaGENE

Cardiometabolic diseases, such as diabetes, hypertension, and cardiovascular disease, result from complex interactions between genetic and environmental factors. This project aims to identify genetic variants associated with these conditions, as well as with health-related traits such as cholesterol levels, blood pressure, body weight, height, and blood cell measurements, using data from CARTaGENE participants. The analyses have already contributed to a better understanding of the genetic architecture of cardiometabolic traits in the Quebec population and to the evaluation of genetic risk scores that estimate an individual’s risk of developing cardiovascular disease. The findings show that these scores can identify people at particularly high risk of coronary artery disease, with risk levels comparable to those observed in some rare inherited forms of the disease. This work contributes to a better understanding of the genetic basis of cardiometabolic diseases and supports the development of more personalized approaches to disease prevention and precision medicine.

• Chronic diseases
• Genetics and genomics

• Biochemical and hematological data
• Genetic data
• Physical and cognitive measures
• Questionnaire data