Evaluation of genetic variants identified through hereditary cancer gene discovery projects in a French Canadian control cohort

Some families are more affected by cancer because they carry genetic changes that can be passed from one generation to the next. However, it is not always clear whether a genetic change truly increases cancer risk or is simply a common variation found in the population. This project uses genetic data from CARTaGENE participants to better understand which genetic variations are associated with a higher risk of inherited cancers in the French-Canadian population. The research has helped identify genetic changes linked to an increased risk of certain cancers while showing that other previously suspected variants do not appear to increase cancer risk. It has also contributed to the discovery and evaluation of new genes that may play a role in hereditary breast cancer. These findings help improve the interpretation of genetic test results and support more accurate cancer risk assessment for individuals and families.

• Cancer
• Genetics and genomics

• Biological samples
• Questionnaire data