Genomic Analysis of the Mitochondrial Transcriptome

Mitochondria are small structures found in nearly all cells of the body and are responsible for producing the energy needed for cells to function. This project used genetic and molecular data from CARTaGENE participants to better understand how mitochondrial genes work and why they function differently from one person to another. The research identified genetic factors that influence how mitochondrial genes are activated, regulated, and processed within cells. It also improved understanding of the interactions between the mitochondrial genome and the rest of a person’s genetic makeup. The findings suggest that inherited differences in these biological processes may contribute to the risk of common diseases, including cardiovascular, metabolic, and neurological conditions. Overall, this work provides new insights into the role of mitochondria in human health and disease and may help guide the development of future prevention and treatment strategies.

• Genetics and genomics

• Biochemical and hematological data
• Genetic data
• Questionnaire data