Role of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis

Status Ongoing
Start date 2018
Location Quebec
Researcher Moreau, Alain
Associated institution Centre Hospitalier Universitaire Sainte-Justine and Université de Montréal
Summary

Osteoarthritis is the most common joint disease and one of the leading causes of disability among aging adults. Despite its high prevalence, the biological mechanisms driving the onset and progression of the disease are still not fully understood. This project investigates the role of two proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), as well as a cellular regulatory process known as SUMOylation, in the development of osteoarthritis. Using CARTaGENE data and biological samples, researchers are evaluating whether these molecules could serve as biomarkers to identify individuals at risk of developing osteoarthritis or experiencing faster disease progression. The study also explores how aging, oxidative stress, hormonal changes, and alterations in cartilage and bone cells contribute to the disease. In the long term, this research may help identify early diagnostic markers and support the development of new therapies targeting the biological mechanisms involved in osteoarthritis.

Themes
  • Chronic diseases
  • Genetics and genomics
  • Methodology and biostatistics
Data types
  • Biological samples
  • Genetic data
  • Linked data
  • Physical and cognitive measures
  • Questionnaire data

Related resources