Publications
2021
R. Jantzen, Y. Payette, T. de Malliard, C. Labbé, N. Noisel, P. Broët, Validation of breast cancer risk assessment tools on a French-Canadian population-based cohort, BMJ Open 11 (4)
C. S. Moura, Y. Payette, C. Boileau, M. Abrahamowicz, L. Pilote, Agreement in the CARTaGENE cohort between self-reported medication use and claim data, Chronic Illn
I. E. Elkholi, M. Di Iorio, S. Fahiminiya, S. L. Arcand, H. Han, C. Nogué, S. Behl, N. Hamel, S. Giroux, M. de Ladurantaye, O. Aleynikova, W. H. Gotlieb, J.-F. Côté, F. Rousseau, P. N. Tonin, D. Provencher, A.-M. MesMasson, M. R. Akbari, B. Rivera, W. D. , Investigating the causal role of MRE11A p.E506* in breast and ovarian cancer, Sci Rep. 11 (1): 2409
A. Béliveau, A-M Castilloux, C. Tannenbaum, P. Vincent, C. Soares de Moura, S. Bernatsky, Y. Moride, Predictors of long-term use of prescription opioids in the community-dwelling population of adults without a cancer diagnosis: a retrospective cohort study, CMAJ Open. 9 (1) : E96-E106
T. Meng, S. Kubow, D. E. Nielsen, Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults, Int J Obes
2020
J. Duhazé, R. Jantzen, Y. Payette, T. De Malliard, C. Labbé, N. Noisel, P. Broët, Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort, Front Genet. 11:408
N. Power, S.S. Deschênes, F. Ferri, N. Schmitz, The Association Between Job Strain, Depressive Symptoms, and Cardiovascular Disease Risk: Results From a Cross-Sectional Population-Based Study in Québec, Canada, Int Arch Occup Environ Health.
N. Zhao, A. Smargiassi, M. Hatzopoulou, I. Colmegna, M. Hudson, M.J. Fritzler, P. Awadalla, S. Bernatsky, Long-term exposure to a mixture of industrial SO 2, NO 2, and PM 2.5 and anti-citrullinated protein antibody positivity, Environ Health. 19(1):86
F. Akçimen, J. P. Ross, F. Sarayloo, C. Liao, R. De Barros Oliviera, J. A. Ruskey, C. V. Bourassa, P.A. Dion, L. Xiong, Z. Gan-Or, G.A. Rouleau, Genetic and epidemiological characterization of restless legs syndrome in Québec., Sleep. zsz265
N. Zhao, A. Smargiassi, I. Colmegna, M. Hudson, M. Fritzler, S. Bernatsky, Sunlight exposure, sun-protective behaviour, and anti-citrullinated protein antibody positivity: A general population-based study in Quebec, Canada, Arthritis Care Res.
N. Power, S.S. Deschênes, F. Ferri, N. Schmitz, Job strain and the incidence of heart diseases: A prospective community study in Quebec, Canada, J Psychosom Res. 139:110268
A.T. Ali, Y. Idaghdour, A. Hodgkinson , Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes, Commun Biol. 3(1):147
H.Y. Han, C. Paquet, L. Dubé, D.E. Nielsen, Diet Quality and Food Prices Modify Associations between Genetic Susceptibility to Obesity and Adiposity Outcomes, Nutrients. 12(11):E3349
L.C. Desbiens, R. Goupil, F. Madore, F. Mac-Way, Incidence of fractures in middle-aged individuals with early chronic kidney disease: a population-based analysis of CARTaGENE, Nephrol Dial Transplant. gfz259
H. C. Gerstein, E. E. Smith, C. Ramasundarahettige, D. Desai, P. Awadalla, P. Broet, S. Black, T. J. B. Dummer, J. Hicks, A. Moody, J-C Tardif, K. K. Teo, J. Vena, S. Yusuf, D. S. Lee, M. G. Friedrich, S. S. Anand, Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study, J Clin Endocrinol Metab.
M. Khalili, F. Lepeytre, J. Guertin, R. Goupil, S. Troyanov, J. Bouchard, F. Madore, Impact of updated recommendations on acetylsalicylic acid use for primary prevention of cardiovascular disease in Canada: a population-based survey, CMAJ Open. 8(1): E41-E47
R. E. Hall, N. Tusevljak, C. F. Wu, Q. Ibrahim, K. Schulze, A. M. Khan, D. Desai, P. Awadalla, P. Broet, T. J. B. Dummer, J. Hicks, J-C Tardif, K. K. Teo, J. Vena, D. Lee, M. Friedrich, S. S. Anand, J.Tu, The Canadian Alliance for Healthy Hearts and Minds: How Well Does It Reflect the Canadian Population?, CJC Open 2(6):599-609
L.C. Desbiens, A. Sidibé, C. Beaudoin, S. Jean, F. Mac-Way, Comparison of Fracture Prediction Tools in Individuals Without and With Early Chronic Kidney Disease: A Population-Based Analysis of CARTaGENE, J Bone Miner Res. 35(6):1048-1057
F. Lamarche, M. Agharazii, F. Madore, R. Goupil, Prediction of Cardiovascular Events by Type I Central Systolic Blood Pressure, Hypertension.
S.S. Deschênes, R. J. Burns, N. Schmitz, Anxiety and Depression Symptom Comorbidity and the Risk of Heart Disease: A Prospective Community-Based Cohort Study, Psychosom Med. 82(3):296-304
Floriana Ferri,Sonya S. Deschênes,Niamh Power & Norbert Schmitz, Association between depressive symptoms, metabolic risk factors, and cognitive function: cross-sectional results from a community study in Quebec, Canada, Aging Ment Health.
N. Zhao, A. Smargiassi, M. Hudson, M. J. Fritzler, S. Bernatsky, Investigating associations between anti-nuclear antibody positivity and combined long-term exposures to NO2, O3, and PM2.5 using a Bayesian kernel machine regression approach, Envrion Int. 136:105472
H. C. Gerstein, E. E. Smith, C. Ramasundarahettige, D. Desai, P. Awadalla, P. Broet, S. Black, T. J. B. Dummer, J. Hicks, A. Moody, J-C Tardif, K. K. Teo, J. Vena, S. Yusuf, D. S. Lee, M. G. Friedrich, S. S. Anand, Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study, J Clin Endocrinol Metab.
S. Anand, M. Friedrich, D. Desai, K. Schulze, P. Awadalla, et al., Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury, Stroke. 51(4):1158-1165
Y. Payette, C.S. De Moura, C. Boileau, S. Bernatsky, N. Noisel, Is there an agreement between self-reported medical diagnosis in the CARTaGENE cohort and the Québec administrative health databases?, IJPDS. 5(1): 16
M.E. Dupuis, A.C. Nadeau-Fredette, F. Madore, M. Agharazii, R. Goupil, Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals, JAMA Netw Open. 3(4): e202377
S. Behl, N. Hamel, M. de Ladurantaye, S. Lepage, R. Lapointe, A.M. Mes-Masson, W.D. Foulkes, Founder BRCA1/BRCA2/PALB2 pathogenic variants in French-Canadian breast cancer cases and controls, Sci Rep. 10(1): 6491
2019
F. Allum, Å.K. Hedman, X. Shao, W.A. Cheung, J. Vijay, F. Guénard, T. Kwan, M.M. Simon, B. Ge, C. Moura, L. Rönnblom, S. Bernatsky, M. Lathrop, M.I. McCarthy, P. Deloukas, A. Tchernof, T. Pastinen, M.C. Vohl, E. Grundberg, Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements, Nat Commun. 10(1):1209
X. Shao, M. Hudson, I. Colmegna, C.M.T. Greenwood, M.J. Fritzler, P. Awadalla, T. Pastinen, S. Bernatsky, Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing., Clin Epigenetics. 11(1):110
S.S. Anand, J. Tu, P. Awadalla, P. Robson, S. Jacquemont, et al. , Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease, Eur Heart J Cardiovasc Imaging. 21(6):692-700
L. C. Desbiens, R. Goupil, F. Mac-Way, Predictive value of quantitative ultrasound parameters in individuals with chronic kidney disease: A population-based analysis of CARTaGENE, Bone. 115120
S. Glentis, A. C. Dimopoulos, K. Rouskas, G. Ntritsos, E. Evangelou, S. A. Narod, A. M. Mes-Masson, W. D. Foulkes, B. Rivera, P. N. Tonin, J. Ragoussis, A. S. Dimas, Exome Sequencing in BRCA1- and BRCA2-Negative Greek Families Identifies MDM1 and NBEAL1 as Candidate Risk Genes for Hereditary Breast Cancer., Front Genet. 18(10): 1005
A. Krajcoviechova, F.C. Marois-Blanchet, S. Troyanov, F. Harvey, P. Dumas, J. Tremblay, R. Cifkova, P. Awadalla, F. Madore, P. Hamet, Uromodulin in a pathway between decreased renal urate excretion and albuminuria, Am J Hypertens. 32(4):384-392
D. Nielsen, Y. Han, C. Paquet, AK. Portella, Y. Ma, L. Dube, Interaction of DRD2/ANKK1 Taq1A Genotype with in-Store Retail Food Environment Exposures on Diet Quality in a Cohort of Quebec Adults, Lifestyle Genom. 13(1) : 1-52
P. Hystad, Y. Payette, N. Noisel, C. Boileau, Green space associations with mental health and cognitive function, Environ Epidemiol. 3(1):e040
A.T. Ali, L. Boehme, G. Carbajosa, V.C. Seitan, K.S. Small, A. Hodgkinson, Nuclear genetic regulation of the human mitochondrial transcriptome, eLife. 8:e41927
L.-C. Desbiens, R. Goupil, A. Sidibé, F. Madore, F. Mac-Way, Fracture status in middle-aged individuals with early CKD: cross-sectional analysis of the CARTaGENE survey, Osteoporos Int. 30(4):787-795
Z. Slim, C.S. Moura, S. Bernatsky, E. Rahme, Identifying Rheumatoid Arthritis Cases Within the Quebec Health Administrative Database, J Rheumatol. 46(12):1570-1576
Z. Slim, C.S. Moura, S. Bernatsky, E. Rahme, Care quality for rheumatoid arthritis patients in Quebec, Int J Rheum Dis. 22(7):1233-1238
I. Fortier, N. Dragieva, M. Saliba, C. Craig, P.J. Robson; with the Canadian Partnership for Tomorrow Project’s scientific directors and the Harmonization Standing Committee, Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis, CMAJ Open. 7(2):E272-E282
F. Wünnemann, K.S. Lo, A. Langford-Avelar, D. Busseuil, M.P. Dubé, J.C. Tardif, G. Lettre , Validation of Genome-wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians, Circ Genom Precis Med. 12(6):e002481
H.D. Hosgood III, M. Klugman, K. Matsuo, A.J. White, A. Sadakane, X.O. Shu, R. Lopez-Ridaura, A. Shin, I. Tsuji, R. Malekzadeh, Nolwenn Noisel et al., The Establishment of the Household Air Pollution Consortium (HAPCO), Atmos. 10(7): 422
S.S Deschênes, R.J. Burns, E. Graham, N. Schmitz, Depressive symptoms and sleep problems as risk factors for heart disease: a prospective community study, Epidemiol Psychiatr Sci. 1-10
2018
R. Goupil, M. Lamarre-Cliche, M. Vallée, The 2017 American College of Cardiology/American Heart Association vs Hypertension Canada High Blood Pressure Guidelines and Potential Implications, Can J Cardiol. 34(5):665-669
T.J.B. Dummer, P. Awadalla, C. Boileau, C. Craig, I. Fortier, V. Goel, J.M.T. Hicks, S. Jacquemont, B.M. Knoppers, N. Le, T. McDonald, J. McLaughlin, A.M. Mes-Masson, A.M. Nuyt, L.J. Palmer, L. Parker, M. Purdue, et al., The Canadian Partnership for Tomorrow Project: a pan-Canadian platform for research on chronic disease prevention, CMAJ. 190(23):E710-E717
R.J. Burns, S.S. Deschênes, N. Schmitz, Associations between Depressive Symptoms and Indices of Obesity in Adults with Prediabetes and Normal Blood Glucose Levels: Results From the Emotional Health and Wellbeing Study, Can J Diabetes. 42(6):626-631
S. Boies, C. Mérette, T. Paccalet, M. Maziade, A. Bureau, Polygenic risk scores distinguish patients from non-affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi-affected kindreds, Am J Med Genet B Neuropsychiatr Genet. 177(3):329-336
S. Peischl, I. Dupanloup, A. Foucal, M. Jomphe, V. Bruat, J.C. Grenier, A. Gouy, K.J. Gilbert, E. Gbeha, L. Bosshard, E. Hip-Ki, M. Agbessi, A. Hodgkinson, H. Vézina, P. Awadalla, L. Excoffier, Relaxed Selection During a Recent Human Expansion, Genetics. 208(2):763-777
F. Lamarche, M. Agharazii, A.C. Nadeau-Fredette, F. Madore, R. Goupil, Central and Brachial Blood Pressures, Statins, and Low-Density Lipoprotein Cholesterol: A Mediation Analysis, Hypertension. 71(3):415-421
F. Lepeytre, P. L. Lavoie, S. Troyanov, F. Madore, M. Agharazii, R. Goupil, Uric acid association with pulsatile and steady components of central and peripheral blood pressures, J Hypertens. 36(3):495-501
M.J. Favé, F.C. Lamaze, D. Soave, A. Hodgkinson, H. Gauvin, V. Bruat, J.C. Grenier, E. Gbeha, K. Skead, A. Smargiassi, M. Johnson, Y. Idaghdour, P. Awadalla, Gene-by-environment interactions in urban populations modulate risk phenotypes, Nat Commun. 9(1):827
D. Nada, C. Julien, M.E. Samuels, A. Moreau, A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population, Spine (Phila Pa 1976). 43(3):172-178
2017
A. Gravel, I. Dubuc, A. Brooks-Wilson, K.J. Aronson, J. Simard, H.A. Velásquez-García, J.J. Spinelli, L. Flamand, Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer, Cancer Epidemiol Biomarkers Prev. 26(3):425-427
M. Tremblay, G. Rouleau, Deep genealogical analysis of a large cohort of participants in the CARTaGENE project (Quebec, Canada), Ann Hum Biol. 44(4):357-365
C. Dias, M. Giordano, R. Frechette, S. Bellone, C. Polychronakos, L. Legault, C.L. Deal, C.G. Goodyer, Genetic variations at the human growth hormone receptor (GHR) gene locus are associated with idiopathic short stature, J Cell Mol Med. 21(11):2985-2999
S. Bernatsky, A. Smargiassi, L. Joseph, P. Awadalla, I. Colmegna, M. Hudson, M.J. Fritzler, Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies, Environ Res. 157:60-63
D.A. Knowles, J.R. Davis, H. Edgington, A. Raj, M.J. Favé, X. Zhu, J.B. Potash, M.M. Weissman, J. Shi, D. Levinson, P. Awadalla, S. Mostafavi, S.B. Montgomery, A. Battle, Allele-specific expression reveals interactions between genetic variation and environment, Nat Methods. 14(7):699-702
A.M. Drucker, A.A. Qureshi, T.J.B. Dummer, L. Parker, W.Q. Li, Atopic dermatitis and risk of hypertension, type 2 diabetes, myocardial infarction and stroke in a cross-sectional analysis from the Canadian Partnership for Tomorrow Project, Br J Dermatol. 177(4):1043-1051
2016
S. Troyanov, C. Delmas-Frenette, G. Bollée, S. Youhanna, V. Bruat, P. Awadalla, O. Devuyst, F. Madore, Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion, Clin J Am Soc Nephrol. 11(1): 62-69
A. Hodgkinson, J.C. Grenier, E. Gbeha, P. Awadalla, Haplotype-based normalization technique for the analysis and detection of allele specific expression, BMC Bioinformatics. 17(1): 364
N.D. Merner, A. Mercado, A.R. Khanna, A. Hodgkinson, V. Bruat, P. Awadalla, G. Gamba, G.A. Rouleau, K.T. Kahle, Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia, J Psychiatr Res. 77: 22-26
R. Goupil, D. Dupuis, S. Troyanov, F. Madore, M. Agharazii, Heart rate dependent and independent effects of beta-blockers on central hemodynamic parameters: a propensity score analysis, J Hypertens. 34(8): 1535-1543
S.S. Deschênes, R.J. Burns, E. Graham, N. Schmitz, Prediabetes, depressive and anxiety symptoms, and risk of type 2 diabetes: A community-based cohort study, J Psychosom Res. 89:85-90
R. Goupil, D. Dupuis, M. Agharazii, P. Hamet, S. Troyanov, F. Madore, Central blood pressures in early chronic kidney disease: an analysis of CARTaGENE, Nephrol Dial Transplant. 32(6):976-983
N. Schmitz, S.S. Deschênes, R.J. Burns, K.J. Smith, A. Lesage, I. Strychar, R. Rabasa-Lhoret, C. Freitas, E. Graham, P. Awadalla, J.L. Wang, Depression and risk of type 2 diabetes: the potential role of metabolic factors, Mol Psychiatry. 21(12):1726-1732
S.S. Anand, J.V. Tu, P. Awadalla, S. Black, C. Boileau, D. Busseuil, D. Desai, J.P. Despres, R.J. de Souza, T.J.B. Dummer, S. Jacquemont, B.M. Knoppers, E. Larose, S.A. Lear, F. Marcotte, A.R. Moody, L. Parker, P. Poirier, et al., Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) - a Pan Canadian cohort study, BMC Public Health. 32(6):976-983
K.R. Kukurba, P. Parsana, B. Balliu, K.S. Smith, Z. Zappala, D.A. Knowles, M.J. Favé, J.R. Davis, X. Li, X. Zhu, J.B. Potash, M.M. Weissman, J. Shi, A. Kundaje, D.F. Levinson, P. Awadalla, S. Mostafavi, A. Battle, S.B. Montgomery, Impact of the X Chromosome and sex on regulatory variation, Genome Res. 26(6):768-77
2015
C.S. Moura, S.S. Daskalopoulou, L.E. Levesque, S. Bernatsky, M. Abrahamowicz, M.A. Tsadok, S. Rajabi, L. Pilote, Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic Patients, J Clin Hypertens. 17(11): 848-854
J.G. Hussin, A. Hodgkinson, Y. Idaghdour, J.C. Grenier, J.P. Goulet, E. Gbeha, E. Hip-Ki, P. Awadalla, Recombination affects accumulation of damaging and disease-associated mutations in human populations, Nat Genet. 47(4): 400-404
R. El-Bikai, M.R. Tahir, J. Tremblay, M. Joffres, O. Seda, L. Sedova, P. Awadalla, C. Laberge, B.M. Knoppers, P. Dumas, D. Gaudet, L.G. Ste-Marie, P. Hamet, Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals, J Hypertens. 33(4): 727-735
A. Gravel, I. Dubuc, G. Morissette, R.H. Sedlak, K. R. Jerome, L. Flamand, Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris, Proc Natl Acad Sci U S A. 112(26):8058-63
2014
K.T. Kahle, N. D. Merner, P. Friedel, L. Silayeva, B. Liang, A. Khanna, Y. Shang, P. Lachance-Touchette, C. Bourassa, A. Levert, P.A. Dion, B. Walcott, D. Spiegelman, A. Dionne-Laporte, A. Hodgkinson, P. Awadalla, H. Nikbakht, J. Majewski, P. Cossette, Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy, EMBO Rep. 15(7): 766-774
J.C. Verhave, S. Troyanov, F. Mongeau, L. Fradette, J. Bouchard, P. Awadalla, F. Madore, Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care, Clin J Am Soc Nephrol. 9(4): 713-719
A. Hodgkinson, Y. Idaghdour, E. Gbeha, J.C. Grenier, E. Hip-Ki, V. Bruat, J.P. Goulet, T. de Malliard, P. Awadalla, High-resolution genomic analysis of human mitochondrial RNA sequence variation, Science. 344(6182): 413-415
2013
D. Doiron, P. Raina and I. Fortier, Linking Canadian population health data: maximizing the potential of cohort and administrative data, Can J Public Health. 104(3): e258–e261
P. Awadalla, C. Boileau, Y. Payette, Y. Idaghdour, J. P. Goulet, B.M. Knoppers, P. Hamet, C. Laberge, Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics, Int J Epidemiol. 42(5): 1285-1299
2011
S. Fortin, S. Pathmasiri, R. Grintuch, M. Deschênes, Access arrangements' for biobanks: a fine line between facilitating and hindering collaboration, Public Health Genomics. 14(2): 104-114
2007
B. Godard, J. Marshall, C. Laberge, Community engagement in genetic research: results of the first public consultation for the Quebec CARTaGENE project, Community Genet. 10(3): 147-158
2006
Y. Joly, B.M. Knoppers, Pharmacogenomic data sample collection and storage: ethical issues and policy approaches, Pharmacogenomics. 7(2): 219-226
2004
B. Godard, J. Marshall, C. Laberge, B.M. Knoppers, Strategies for consulting with the community: the cases of four large-scale genetic databases, Sci Eng Ethics. 10(3): 457-477
Projects
2020
Characterization of psychiatric polygenic determinants in Quebec Principal Investigator: Guy Rouleau
Affiliation: McGill
Habitudes de vie, métabolites plasmatiques et santé cardiovasculaire dans une cohorte d’individus avec hypercholestérolémie familiale hétérozygote Principal Investigator: Jean-Philippe Drouin-Chartier
Affiliation: Université Laval
Susceptibility genes and molecular drivers of lung cancer Principal Investigator: Yohan Bossé
Affiliation: Université Laval
Investigating the role of non-coding variations in epilepsy Principal Investigator: Simon Girard
Affiliation: Université du Québec à Chicoutimi
Investigation of Biomarkers of Radiation Exposure in Radon Cohorts Principal Investigator: Vinita Chauhan
Affiliation: Santé Canada
Genomics Deep Learning Principal Investigator: Ali Torkamani
Affiliation: The Scripps Research Institute
Using CARTaGENE data for the proof of concept research project of ARCHI (PRECINOMICS pilot): Study of genetic and clinical risk factors for cancer and cardiovascular disease Principal Investigator: Marie-Pierre Dubé
Affiliation: Institut de cardiologie de Montréal
2019
Depression, metabolic factors and the risk of cancer: prospective associations in the CARTaGENE study Principal Investigator: Norbert Schmitz
Affiliation: McGill
The genetic basis of hair and eye color in Canadians of European Ancestry (CanPath) Principal Investigator: Esteban Parra
Affiliation: University of Toronto
Phénotype de polymorphismes du récepteur NTS1 de la neurotensine Principal Investigator: Philippe Sarret
Affiliation: Université de Sherbrooke
Lifestyle and environmental factors, DNA methylation and lung cancer risk Principal Investigator: Vikki Ho
Affiliation: CRCHUM
Genetic Variants Associated with Pain Reduction in Patients with Low Back Pain or Neuropathic Pain Principal Investigator: Luda Diatchenko
Affiliation: McGill University
Évaluation des biomarqueurs de sénescence cellulaire chez les participants de la cohorte CARTaGENE Principal Investigator: Francis Rodier
Affiliation: CRCHUM
Evaluation of predictive models on the occurrence of breast cancer at 5 years Principal Investigator: Philippe Broët
Affiliation: CHU Ste-Justine, Université de Montréal
Essential Tremor Genome-wide Association Study Principal Investigator: Guy Rouleau
Affiliation: McGill
Aging-induced dysregulation of gene expression networks Principal Investigator: Alan Cohen
Affiliation: Université de Sherbrooke
Zoonoses : Changements climatiques et zoonoses priorisées : portrait de situation à l’aide des données de la cohorte populationnelle québécoise CARTaGENE et établissement de projets de surveillance et de recherche Principal Investigator: Nolwenn Noisel, Ariane Adam-Poupart
Affiliation: INSPQ
Nutritional, behavioral and lifestyle mediators of genetic susceptibility to obesity Principal Investigator: Louis Pérusse
Affiliation: Université Laval
Characterization of Quebec population structure Principal Investigator: Simon Gravel
Affiliation: McGill University
Lifestyle and Cancer: Identifying new risk factors for the most common cancers in Canada Principal Investigator: Rachel Murphy
Affiliation: The Université of British Columbia
Environnement bâti et santé Principal Investigator: Éric Robitaille
Affiliation: INSPQ
Signatures of cardiovascular health derived from integrated biomics, environment and lifestyle – findings from the Canadian Alliance for Healthy Hearts and Minds – CARTaGENE cohort Principal Investigator: Matthias Friedrich
Affiliation: MUHC
Évaluation de l’exposition des travailleurs à la chaleur à l’aide des données de la cohorte québécoise CARTaGENE Principal Investigator: Nolwenn Noisel
Affiliation: CARTaGENE - CHU Sainte-Justine / École de santé publique
2018
Occupational exposure to endocrine disrupting chemicals and colorectal cancer risk Principal Investigator: Vikki Ho
Affiliation: CRCHUM
Genetic analyses of proposed new ovarian cancer predisposing gene Principal Investigator: Patricia Tonin
Affiliation: McGill University Health Centre
An investigation of gene-environment interaction on eating behaviour and adiposity in a cohort of Quebec adults Principal Investigator: Daiva Nielsen
Affiliation: McGill University
Population genetics of pharmacogenes Principal Investigator: Julie Hussin
Affiliation: Institut de Cardiologie de Montréal Centre de Recherche - Université de Montréal
Phenome-wide AssociatioN studies of cardiometabolic Drug tArgets (PANDA) Principal Investigator: Benoit Arsenault
Affiliation: Institut universitaire de cardiologie et de pneumologie de Québec –Université Laval
Prévalence de variantes dans les gènes NPC1 et NPC2 dans la population québécoise Principal Investigator: Martine Tétreault
Affiliation: Centre hospitalier de l’Université de Montréal - CHUM
EpiCan (CanPath) Principal Investigator: Philip Awadalla
Affiliation: OICR
Role of Prohibitins and SUMOylation in Osteoarthritis Pathogenesis Principal Investigator: Alain Moreau
Affiliation: Centre Hospitalier Universitaire Sainte-Justine
Canadian Alliance for Healthy Hearts and Minds (CAHHM) (CanPath) Principal Investigator: Sonia Anand
Affiliation: McMaster
Exposure to ultraviolet radiation and the risk of hematologic malignancy and other site-specific cancer development Principal Investigator: Will King
Affiliation: Queens University
Étude de prévalence de l'antigène de groupe sanguin D faible type 42 Principal Investigator: Josée Laganière
Affiliation: Héma-Québec
Provincial Variation in Cancer Screening Uptake Across Canada: A Descriptive Overview (CanPath) Principal Investigator: Trevor Dummer
Affiliation: UBC
2017
Genetic basis and modifiers of sleep disorders Principal Investigator: Simon Warby
Affiliation: Hôpital Sacré-Coeur de Montréal
Estimation de la prévalence de certaines mutations associées à un risque accru de cancer du sein, ainsi que du risque qui leur sont associées Principal Investigator: Jacques Simard
Affiliation: CHU de Québec
SNP discovery in myalgic encephalomyelitis (ME) Principal Investigator: Alain Moreau
Affiliation: CHU Ste-Justine
Genetics of REM sleep behavior disorder and conversion to Parkinson's disease Principal Investigator: Ziv Gan Or
Affiliation: McGill University
Marqueurs Ostéocytaires, Fractures et Évènements Cardiovasculaires en Insuffisance Rénale Chronique (MOFECIRC) Principal Investigator: Fabrice Mac-Way
Affiliation: Université Laval
Comparative Genomewide Association of Aortic Stenosis With and Without Coronary Artery Disease Principal Investigator: George Thanassoulis
Affiliation: McGill University Health Centre
Occupational Physical Activity and Lung Cancer Principal Investigator: Vikki Ho
Affiliation: CRCHUM
Genetic analyses of cardiometabolic diseases and traits in CARTaGENE Principal Investigator: Guillaume Lettre
Affiliation: Institut de Cardiologie de Montréal Centre de Recherche
Quantifying the Cancer Incidence Burden due to Lifestyle and Environment in Canada - The Canadian Population Attributable Risk of Cancer Project (ComPARe) (CanPath) Principal Investigator: Darren Brenner
Affiliation: AHS
The impact of structural genomic variants on cognition in the general population Principal Investigator: Sébastien Jacquemont
Affiliation: CHU Sainte-Justine
Systemic inflammation and the risk of depression in people with type 2 diabetes: a prospective community study Principal Investigator: Norbert Schmitz
Affiliation: Douglas Mental Health University Institute
Pharmacogenetic study exploring the impact of a genetic variant in the CYP2R1 gene on the response to vitamin D replacement therapy Principal Investigator: Brent Richards
Affiliation: Lady Davis Institute - Jewish General Hospital
Evaluation of genetic variants identified through hereditary cancer gene discovery projects in a French Canadian control cohort Principal Investigator: William Foulkes
Affiliation: McGill University Health Centre
2016
Deciphering the Genetic background of Restless Legs Syndrome Principal Investigator: Guy Rouleau
Affiliation: Institut neurologique de Montréal, Université McGill
Genomic follow-up of the susceptibility loci for schizophrenia and bipolar disorder in multi-affected families of Eastern Quebec Principal Investigator: Michel Maziade
Affiliation: Université Laval
Poor sleep and mental health: independent or overlapping risk factors for heart diseases? Principal Investigator: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
Association between eczema and cardiovascular and cerebrovascular morbidity (CanPath) Principal Investigator: Aaron Drucker
Affiliation: Brown University
Genomic Analysis of the Mitochondrial Transcriptome Principal Investigator: Alan Hogkinson
Affiliation: King's College London
Understanding different approaches of harmonization using individual participant data to investigate the determinants (CanPath) Principal Investigator: Isabel Fortier
Affiliation: Maelstrom, Université McGill
L'étude du rôle prédicteur de la pression aortique centrale dans la survenue d'événements cardiovasculaires Principal Investigator: Rémi Goupil
Affiliation: Hôpital Sacré-Coeur de Montréal
2015
Simultaneous systematic monitoring of hormonal pathways in bipolar disorder using LC-based targeted and untargeted metabolomics Principal Investigator: Dajana Vuckovic
Affiliation: Université Concordia
Clinical implementation and Outcomes Evaluation of Blood-Based biomarkers for COPD management Principal Investigator: Elizabeth MacNamara
Affiliation: Hôpital général juif
Vegetarian diet, the metabolic syndrome, obesity and inflammatory status Principal Investigator: Isabel Fortier
Affiliation: Maelstrom, Université McGill
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Principal Investigator: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Identification of genes involved in adolescent idiopathic Scoliosis Principal Investigator: Alain Moreau
Affiliation: CHU Sainte-Justine
Evaluation of coronary vascular disease among high cardiovascular risk patients in CARTaGENE Principal Investigator: Thao Huynh
Affiliation: Sanofi
Canadian Alliance for Healthy Hearts and Minds – Development of community health and health services profiles Principal Investigator: Jack Tu
Affiliation: Sunnybrook Health Sciences Centre
2014
Human Growth Hormone Receptor: regulation of expression during development Principal Investigator: Cynthia Goodyer
Affiliation: Université McGill
Génétique de la Rhinosinusite chronique avec polypose nasale Principal Investigator: Martin Desrosiers
Affiliation: CHUM
Étude bien-être émotionnel, facteurs métaboliques et l’état de santé Principal Investigator: Norbert Schmitz
Affiliation: Institut de santé mentale Douglas, Université McGill
The genome-wide association study of the principal components of the metabolic syndrome enriched with albumin/creatinine ratio regarding the OPTI-THERA research project Principal Investigator: Pavel Hamet
Affiliation: CHUM
Exploring the Potential of CARTaGENE for GIS-Based Epidemiology: A Pilot Study of Green Space and Mental Health Principal Investigator: Nolwenn Noisel
Affiliation: CHU Sainte-Justine, Université de Montréal
2013
Molecular dissection of congenital heart disease in the French Canadian population Principal Investigator: Gregor Andelfinger
Affiliation: CHU Ste-Justine
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (2) Principal Investigator: François Madore
Affiliation: Hôpital Sacré-Coeur
Caractérisation des contributions génomiques et environnementales à la variation des phénotypes cardiovasculaires et métaboliques dans la population du Québec Principal Investigator: Philip Awadalla
Affiliation: CHU Sainte-Justine, Université de Montréal
Plateforme d’Innovation en Génomique des Scolioses Pédiatriques (GSP) : Des Gènes aux Tests - Diagnostiques Complets Principal Investigator: Alain Moreau
Affiliation: CHU Ste-Justine
2012
Comparative Effectiveness Research in the Canadian Partnership for Tomorrow Cohort Principal Investigator: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Développement d’une plateforme pour le diagnostic moléculaire du syndrome de Zellweger au Québec Principal Investigator: Luigi Bouchard
Affiliation: Université de Sherbrooke
Analyse des caractéristiques généalogiques des participants au projet CARTaGENE Principal Investigator: Marc Tremblay
Affiliation: Université du Québec à Chicoutimi
Environment, Epigenetics, and Rheumatic Disease Principal Investigator: Sasha Bernatsky
Affiliation: Centre de santé de l’Université McGill
Conséquences médicales de l’intégration chromosomique de l’herpès virus humain 6 Principal Investigator: Louis Flamand
Affiliation: Université Laval
Test de l’accumulation de mutations délétères lors d’expansions spatiales par séquençage d’exomes Principal Investigator: Laurent Excoffier
Affiliation: Université de Berne, Suisse
2010
Prévalence de l’insuffisance rénale chronique dans la cohorte CARTaGENE (1) Principal Investigator: François Madore
Affiliation: Hôpital Sacré-Coeur
2009
Methylmercury exposure and urinary metabolic profile in Cree people from Northern Quebec Principal Investigator: Pierre Ayotte
Affiliation: Centre de recherche du CHUQ, Université Laval