Identification of genes involved in adolescent idiopathic Scoliosis

Status Ongoing
Start date 2015
Location Quebec
Researcher Moreau, Alain
Associated institution Centre Hospitalier Universitaire Sainte-Justine and Université de Montréal
Summary

Adolescent idiopathic scoliosis is a spinal deformity that affects approximately 2–3% of young people and whose causes remain poorly understood. Research suggests that genetic factors play an important role, but the genes involved have not yet been clearly identified. This project uses CARTaGENE genetic data to compare the genetic profiles of individuals with and without scoliosis. The focus is on identifying rare genetic variants that may contribute to the development of the condition. Findings to date have identified several candidate genes and improved understanding of the biological mechanisms involved in scoliosis. In the long term, this research could support earlier diagnosis and more personalized approaches to treatment for individuals at risk.

Themes
  • Genetics and genomics
  • Methodology and biostatistics
Data types
  • Biological samples
  • Genetic data
  • Physical and cognitive measures
  • Questionnaire data

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