Publications
2026/01/20
Genetic analyses of proposed new ovarian cancer predisposing gene
Status
Completed
Start date
2018
Location
Quebec
Researcher
Tonin, Patricia
Associated institution
The Research Institute of the McGill University Health Centre and McGill University
Summary
A significant proportion of hereditary ovarian cancer cases cannot be explained by BRCA1 or BRCA2 mutations. This project aimed to identify new susceptibility genes by focusing on DNA repair pathways. Genetic analyses identified a rare variant in the FANCI gene, more frequent in the French-Canadian population and associated with impaired DNA repair. Frequency analyses using datasets including CARTaGENE suggest this variant may contribute to cancer risk. The findings highlight the role of multiple rare variants and improve understanding of the genetic basis of ovarian cancer.
Themes
- Cancer
- Genetics and genomics
Data types
- Genetic data
- Questionnaire data
Related resources
Theses and dissertations
2023
A molecular genetic investigation of FANCI as a new candidate ovarian cancer predisposing gene
Theses and dissertations
2023
The genetic analyses of DNA repair pathway genes in French Canadians of Quebec identified new candidate risk variants implicated in hereditary ovarian cancer
Publications
2023/03/08
Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases
Publications
2023/01/20
Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene
Publications
2022/04/30
The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population
Theses and dissertations
2021
Analyzing the genetic landscape of French-Canadian hereditary breast cancer women that carry pathogenic BRCA1 or BRCA2 variants
Publications
2021/12/03