Genetics of Chronic Rhinosinusitis with Nasal Polyposis

Status Completed
Start date 2014
Location Quebec
Researcher Desrosiers, Martin
Associated institution CHUM Research Centre and Université de Montréal
Summary

This project aimed to better understand why some individuals develop chronic rhinosinusitis (CRS), a persistent inflammatory disease of the upper airways whose causes remain poorly defined. The research team sought to identify genetic variations that increase susceptibility to CRS, using genetic association analyses conducted across several Quebec-based cohorts.
After an initial series of studies identifying potentially implicated genes — including some involved in inflammatory pathways — the researchers expanded their analyses by incorporating genotyped CARTaGENE participants as a control group. This approach made it possible to confirm previously observed genetic associations, notably with the TSLP gene, which plays a major role in inflammatory diseases of both the upper and lower airways.
These findings help pave the way for identifying biological mechanisms underlying CRS and could eventually contribute to the development of blood‑based biomarkers useful for diagnosis or clinical management.

Themes
  • Chronic diseases
  • Genetics and genomics
Data types
  • Genetic data